Hi Friends,
I was checking recently my medical paper library (384 papers) and I thought it could be helpful to select the 3 most important ones according to my opinion.
Please find them attached.
Read them deeply if you have time. Awareness is definitely the best weapon against vitiligo
Regards,
Flavio
Replies
Hi Flavio,
I have read many of your posts and share your believe that there is a vitamins, minerals and other things we can do to help our condition or slow progress of disease, but at the end, something else is definite lacking and therefore no cure.
Yesterday I aw that Dr. Matteo Bordignone posted in FB and twitter about his presentation about MIA and that he has induced vit in mice by injecting it.
I know you have been in touch with him, can you ask for a copy of his presentation ? Lets hope that he has a way to block it.
rgds
I do have it, but It's still confidential. Sorry. His presentation was amazing.
He left people like Dr. Harris and Dr. Spritz astonished, as what I saw.
He is my main hope to see a real cure in a short time...
What he did in the mice experiment was:
1- As you know, his hiphotesis is that MIA presence is the cause of vitiligo;
2- He has already collected some epidermis from vitiligo volunteer's patches and confirmed its presence;
3- A known laboratory has also confirmed MIA presence in vitiligo patches as counter-proof;
4- He worked on an animal model, by injecting MIA in some mice tails. Guess what happened? He induced vitiligo in these mice.
5-Different from Caroline Le Poole that ordered genetic modified mice from a lab (with vitiligo) and reverted it by undoing the modification, Dr. Bordignon used ordinary mice. He injected MIA in their tails for a short term and reverted vitiligo by stopping the injections.
6- His theory is based on the fact that vitiligo sufferer's produce MIA by default, when skin is submited by pressure, friction and oxidative stress.
7-MIA is a protein that should be only produced by melanomas, other than melanocytes.
More details: http://www.vitiligomap.com
regards,
Flavio
Thank you for your reply and readings.
Yes I'm aware that vit occurs where there has been friction or old injuries. In my case, I like sports and there might be a connection to my long work out of Sundays and that feeling that the start of the week is my worst enemy for vit. I'l have to control the urge to be exhausted.
well, I'll be counting the weeks, hoping to have that inhibitor soon.
Me too.
In the meantime follow the protocol as much as possible.
http://www.vitiligomap.com/protocol.html
This protocol is a combination of suggestions from Prof Schallreuter, Dr, Matteo Bordignon, Dr Holla, Dr. Susan Blum, Dr. Ray Strand, among others. It's very comprehensive. That's the only one that I personally have seen working.
That's the most we can do so far and it's worth it.
Alternatively, cell transplantation is also a way to get results, but it depends on a previous stable vitiligo condition.
Ja Mad,
He is working on a MIA inhibitor. He is doing trials.
Btw, see the mice picture below (not confidential anymore):
Resultati preliminari=Preliminary result
Iniezione di proteina MIA=Injection of MIA protein
Prima=Before
Dopo=After
Resultati preliminari=Preliminary result
Iniezione di proteina MIA=Injection of MIA protein
Prima=Before
Dopo=After
Conclusion of the first paper:
Detachment and transepidermal elimination of melanocytes following minor mechanical trauma in non lesional vitiligo skin is probably the cause of depigmentation occurring in the isomorphic response (Koebner phenomenon). We propose that transepidermal elimination of melanocytes in vitiligo should be regarded as a possible mechanism of chronic loss of pigment cells, perhaps previously damaged by another process.
It's possible that oxidative stress is the process that previously damaged the cells...
Summary of the first paper (by A. Taieb):
In vitiligo, melanocytes are gradually lost in depigmented macules of the skin. The disappearance of melanocytes has, however, not been clearly observed and consequently the aetiology of the disease (autoimmune, neural, cytotoxic) is still elusive. The starting point of vitiligomacules is frequently determined by local conditions such as wounds and excoriations, but may also follow minor traumas such as pressure or repeated friction. This prominent feature is often neglected.
http://www.vitiligofriends.org/forum/topics/vitiligo-on-face-sugges...